首页> 外文OA文献 >Design and synthesis of new Zn(II) nalidixic acid-DACH based Topo-II inhibiting molecular entity: Chemotherapeutic potential validated by its in vitro binding profile, pBR322 cleavage activity and molecular docking studies with \DNA\ and \RNA\ molecular targets

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Design and synthesis of new Zn(II) nalidixic acid-DACH based Topo-II inhibiting molecular entity: Chemotherapeutic potential validated by its in vitro binding profile, pBR322 cleavage activity and molecular docking studies with \DNA\ and \RNA\ molecular targets

机译：基于Zn（II）萘啶酸-DACH的Topo-II抑制分子实体的设计与合成：通过其体外结合谱，pBR322裂解活性和与\ DNA \和\ RNA \分子靶的分子对接研究验证了化学治疗的潜力

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International audience

机译：国际观众

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Arjmand, Farukh; Yousuf, Imtiyaz; Afzal, Mohd.; Toupet, Loïc;
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年度 2014
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1. Design and synthesis of new Zn(II) nalidixic acid-DACH based Topo-II inhibiting molecular entity: Chemotherapeutic potential validated by its in vitro binding profile, pBR322 cleavage activity and molecular docking studies with DNA and RNA molecular targets [J] . Farukh Arjmand, Imtiyaz Yousuf, Mohd. Afzal, Inorganica Chimica Acta . 2014,第Null期

机译：设计和合成新的基于Zn（II）萘啶酸-DACH的Topo-II抑制分子实体：通过其体外结合谱，pBR322裂解活性以及与DNA和RNA分子靶的分子对接研究验证了化学治疗的潜力
2. Synthesis, crystal structure and antiproliferative activity of Cu(II) nalidixic acid-DACH conjugate: Comparative in vitro DNA/RNA binding profile, cleavage activity and molecular docking studies [J] . Farukh Arjm, Imtiyaz Yousuf, Taibi ben Hadda, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2014,第Null期

机译：铜（II）萘啶酸-DACH缀合物的合成，晶体结构和抗增殖活性：体外DNA / RNA结合特征，裂解活性和分子对接研究的比较
3. Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase Iα: In vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines [J] . TabassumS., ZakiM., AfzalM., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2014,第Null期

机译：靶向拓扑异构酶Iα的基于Cu（II）的抗癌化学药物的合成和表征：体外DNA结合，pBR322裂解，分子对接研究和对人癌细胞系的细胞毒性
4. Virtual screening, ADMET profiling, molecular docking and dynamics approaches to search for potent selective natural molecule based inhibitors against metallothionein-III to study Alzheimer's disease [C] . Roy Sandip, Kumar Ajit, Provaznik Ivo IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：虚拟筛选，ADMET分析，分子对接和动力学方法以寻找有效的基于选择性天然分子的金属硫蛋白-III抑制剂来研究阿尔茨海默氏病
5. Structure-based design of mutant proteins: I. Molecular docking studies of amino acid binding to wild-type aminoacyl-tRNA synthetases. II. Structure-based design of mutant aminoacyl-tRNA synthetases for non-natural amino acid incorporation. [D] . Zhang, Deqiang. 2003

机译：基于结构的突变蛋白设计：I.氨基酸与野生型氨酰基tRNA合成酶结合的分子对接研究。二。非天然氨基酸掺入的突变型氨酰基-tRNA合成酶的基于结构的设计。
6. Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design Synthesis Biological Evaluation and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity [O] . Ashraf S. Hassan, Ahmed A. Askar, Ahmed M. Naglah, 2020

机译：新的席夫碱拴住的吡唑部分的发现：设计合成生物学评估和分子对接研究作为具有免疫调节活性的双重靶向DHFR / DNA旋转酶抑制剂。
7. Design and synthesis of new Zn(II) nalidixic acid-DACH based Topo-II inhibiting molecular entity: Chemotherapeutic potential validated by its in vitro binding profile, pBR322 cleavage activity and molecular docking studies with \DNA\ and \RNA\ molecular targets [O] . Arjmand, Farukh, Yousuf, Imtiyaz, Afzal, Mohd., 2014

机译：基于Zn（II）萘啶酸-DACH的Topo-II抑制分子实体的设计和合成：通过其体外结合谱，pBR322裂解活性和与\ DNA \和\ RNA \分子靶的分子对接研究验证了化学治疗的潜力

Design and synthesis of new Zn(II) nalidixic acid-DACH based Topo-II inhibiting molecular entity: Chemotherapeutic potential validated by its in vitro binding profile, pBR322 cleavage activity and molecular docking studies with \DNA\ and \RNA\ molecular targets

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